杨元勇

个人简介:

杨元勇，博士，教授，博士研究生导师，民建会员，出生于1984年10月，2007年毕业于四川大学获学士学位，2012年毕业于新加坡国立大学获博士学位，2012年到2014年在新加坡国立大学化学生物学从事博士后研究工作，2014年下学期进入贵州医科大学药物化学教研室工作，任贵州医科大学药学院中心实验室副主任，获贵州医科大学药学院青年骨干教师，入选第五批贵州省高层次创新性人才（千层次），荣获贵州省自然科学三等奖（第一获奖人），作为副主编编写了电子科技大学出版社的十三五规划教材《基础化学》，被遴选为《Current Chinese Science》编委。主持国家自然科学基金2项，主持省部级科研项目5项，在SCI收录的学术期刊上发表学术论文40余篇，总影响因子>150，获批发明专利4项。

研究方向:

主要从事有机合成以及生物膜抑制剂的开发工作。在有机合成方面利用绿色催化剂或者绿色氧化剂（空气）进行反应探索合成出一系列杂环类化合物和手性化合物，为手性药物开发奠定了基础，同时也实现了空气中氧气的高效利用，阐明了无外加还原剂和过渡金属条件下空气作为氧化剂的应用，为相关杂原子药物的开发奠定了基础。另一方面，在化学合成的基础上进行生物膜抑制剂开发，基于群体感应策略的生物膜抑制剂开发，由于生物么抑制剂不直接杀灭细菌，不会导致细菌应激而产生耐药性，相关研究成果可以为细菌耐药性提供解决思路。

联系方式（邮箱）：pharmyuanyong@qq.com

主持科研项目情况：

1.国家自然科学基金地区基金项目、22061012、空气参与的吲哚酮、喹啉酮和异喹啉酮的绿色反应研究、2021/01-2024/12、40万、在研、主持

2.国家自然科学基金、81660348、基于群体行为控制的鲍曼不动杆菌生物膜抑制剂的设计、合成及其构效关系研究、2017/1-2020/12、37万、结题、主持

3.中国科学院上海药物研究所开放课题、SIMM1903KF-09、基于群体行为控制的鲍曼不动杆菌生物膜抑制剂的设计、合成及其构效关系研究、2019/4-2020/4、10万、结题、主持

4.贵州省科学技术厅、黔科合支撑[2020]4Y208、COVID-19潜在治疗药物氯喹与瑞德西韦的工艺路线优化、2021/01—2022/12、30万、在研、主持

5.贵州医科大学青年领军人才、2023.7-2028.7、200万、主持

发表论文、专利及获奖情况

1. Organo-Catalyzed Intermolecular Dehydrative Coupling Reaction to Prepare Arylacetic Acid Derivatives, Fei Chen, Huidan Geng, Yonglong Zhao, Chun Li, Bing Guo, Lei Tang,a,*andYuanyong Yanga,*Adv. Synth. Catal.2024,366, 502−507.

2. A New Fluorescent Probe for Hydrogen Sulfide Detection in Solution and Living Cells, Wei Feng,* Qicai Xiao, Lu Wang,Yuanyong Yang,*Molecules2023, 28, 6195.

3. Aerobic Dehydrogenative Aromatization in the Preparation of 4‑Aminoquinoline Derivatives by Synergistic Pd/Cu Catalysis, Fei Chen, Huidan Geng, Chun Li, Jianta Wang, Bing Guo, Lei Tang,* and Yuan-Yong Yang*,J. Org. Chem.2023,88, 15589−15596.

4. Protecting-Group-Free Synthesis of Meridianin A−G and Derivatives and Its Antibiofilm Evaluation，Huidan Geng,# Fei Chen,# Yonglong Zhao, Bing Guo, Lei Tang,* and Yuan-Yong Yang,J. Org. Chem.2023, 88,3927-3934.

5. DBU-Catalyzed Aerobic CDC Reaction of Thiophenols, Xuemin Jia, Xiao Ma, Wei Feng, Ji-Quan Zhang, Yonglong Zhao, Bing Guo, Lei Tang,* Yuan-Yong Yang*,J. Org. Chem.2022,87, 16492−16505.

6. Synthesis and antibiofilm evaluation of N-acyl-2-aminopyrimidine derivatives againstAcinetobacter baumannii,Xue-Min Ji, Cheng Cheng, Ting Liu, Yong-Long Zhao, Bing Guo, Lei Tang, Yuan-Yong Yang,* Bioorg. Med. Chem.2022,76, 117095.

7. Li Yingxian, Chen Wei, Zhao Linchun, Zhang Ji-Quan, Zhao Yonglong, Li Chun, Guo Bing, Tang Lei*,Yang Yuan-Yong*,Catalytic N-methyl midation of carboxylic acids under cooperative conditions,RSC Adv.,2022,12, 20550-20554.

8. Qing-Yan Zhang, Fei-Yu Yang, Shang-Gao Liao, Bing Wang, Rui Li, Yong-Xi Dong, Meng Zhou,Yuan-Yong Yang*, Guo-Bo Xu*, Synthesis, Antibacterial Activity, and Structure–Activity Relationship of Fusaric Acid Analogs,Bulletin of the Korean Chemical Society,2021,42, 577-582.

9. Xing-Lan Wang, Xue Bai, Chun-Feng Wu, Yong-Xi Dong, Min Zhang, Ling-Ling Fan, Lei Tang*,Yuan-Yong Yang*, Ji-Quan Zhang*, Direct C(sp3)−H Sulfonylation and Sulfuration Reactions of Isoquinoline-1,3(2H,4H)-diones under Metal-free Conditions,Asian Journal of Organic Chemistry,2021,10, 386-391.

10. Ying-Xian Li, Xiao-Bing Feng, Xue-Min Jia, Huang Jin, Fei Chen, Yong-Long Zhao, Ji-Quan Zhang, Jian-Ta Wang, Bing Guo, Lei Tang*, Yuan-Yong Yang*, Regiodivergent Functionalization of Isoquinoline-1,3(2H,4H)-dione Derivatives via Aerobic Umpolung,Asian Journal of Organic Chemistry,2021,10, 1508-1513.

11. Cheng Cheng, Ying-Xian Li, Xue-Min Jia, Ji-Quan Zhang, Yong-Long Zhao, Wei Feng, Lei Tang* andYuan-Yong Yang*,Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives,RSC Adv.,2020,10, 42912(IF:3.119).

12. Ying-Xian Li, Cheng Cheng, Lei Tang andYuan-Yong Yang*, Palladium catalyzed asymmetric allylic alkylation of isoquinolinedione derivatives in the preparation of quaternary carbon stereocenters,Org. Biomol. Chem.,2020,18, 4551(IF:3.412)

13. Guo Yang, Cheng Cheng, Guo-Bo Xu, Lei Tang, Kim-Lee Chua*,Yuan-Yong Yang*, Synthesis and antibiofilm evaluation of 3-hydroxy-2,3-dihydroquinazolin- 4(1H)-one derivatives against opportunistic pathogen Acinetobacter baumannii,Bioorganic & Medicinal Chemistry,2020,28, 115606(IF:3.073).

14. Cheng Cheng, Ying-Xian Li, Ji-Quan Zhang, Yong-Long Zhao, Lin Zhang, Chun Li, Yu-she Yang, Lei Tang,* andYuan-Yong Yang,*Organo-Catalyzed Asymmetric Amination of 4-Arylisoquinoline- 1,3(2H,4H)-dione Derivatives in the Construction of Quaternary Stereocenters,Adv. Synth. Catal,2019,361, 5317– 5321(IF:5.851)

15. Yuanyong Yang, Yingxian Li, Zhenhua Zhang, Yonglong Zhao, and Wei Feng*, Metal-free N-formylation of 2-aminophenols using dimethylformamide and CSA,Synthetic Communications,2019,49, 8, 1040–1046(IF:1.796)

16. Yuan-Yong Yang,*Guo Yang, Cheng Cheng, Ying-Xian Li, Ji-Quan Zhang, Wei Feng, 5 Yong-Long Zhao, and Lei Tang*,Catalyst-free Cleavage of Amide and C−O Double Bond for the 2 Diastereoselective Synthesis of Trifluoromethyl-Containing 3 Dihydrooxazole Derivatives,Organic. Letters.2019,21, 2236−2240(IF:6.091)

17. Yuanyong Yang*, Yingxian Li, Cheng Cheng, Guo Yang, Shuiying Wan, Jiquan Zhang, Yuanhu Mao, Yonglong Zhao, Lin Zhang, Chun Li, and Lei Tang*, Reductant-Free Aerobic Hydroxylation of Isoquinoline-1,3(2H,4H)‑dione Derivatives,The Journal of Organic Chemistry,2019,84, 2316-2324(IF:4.335)

18. Yuanyong Yang, Yingxian Li, Cheng Cheng, Guo Yang, Jiquan Zhang, Yi Zhang, Yonglong Zhao, Lin Zhang, Chun Li,* Lei Tang* Synthesis of 4‑Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)‑diones.J. Org. Chem.2018,83, 3348−3353.(IF:4.849)