陈文章

个人简介：陈文章，男，讲师。2021年底毕业于比利时Namur大学，获科学博士学位；2021年12月-至今就职于贵州医科大学药学院医药卫生管理学院。

研究方向：致病菌生物膜抑制剂研发及功能化柱芳烃的合成与应用。

联系方式：chenwenzhang@gmc.edu.cn

主持科研项目：主持贵州省市厅级项目4项（包括贵州省科技厅项目2项，贵阳市科技局项目1项，贵州省卫生厅项目1项，贵州医科大学校级项目1项），发表SCI及核心期刊研究论文10余篇，获国家发明专利授权1项。

代表性论文：

[1]. Iuliana M. Andrei^#,Wenzhang Chen^#, Marc Baaden, Stéphane P. Vincent*, Mihail Barboiu*. Proton-versus Cation-Selective Transport of Saccharide Rim-Appended Pillar[5]arene Artificial Water Channels[J],Journal of the American Chemical Society, 2023, 145, 21904−21914.

[2]. Wenzhang Chen^#, Tingxiao Xu^#, Gaofeng Zhu, Bing Guo, Lei Tang, Jianta Wang*. Concise Total Syntheses of Amorfrutin A and B[J],ChemistrySelect,2022, 7(37): e202202968.

[3]. Simon J. L. Petitjean^#,Wenzhang Chen^#, Melanie Koehler, Ravikumar Jimmidi, Jinsung Yang, Danahe Mohammed, Blinera Juniku, Megan L. Stanifer, Steeve Boulant, Stéphane P. Vincent*, David Alsteens*. Multivalent 9-O-Acetylated -sialic acid glycoclusters as potent inhibitors for SARS CoV-2 infection[J],Nature Communications, 2022, 13(1): 2564.

[4].Wenzhang Chen^#, Stéphane P. Vincent*, Copillar[5]arene chemistry: synthesis and applications[J],Synthesis, 2022, 55(02): 246-262.

[5].Wenzhang Chen^#,Tharwat Mohy EI Dine, Stéphane P. Vincent*, Synthesis of functionalized copillar[4+1]arenes and rotaxane as heteromultivalent scaffolds[J],Chemical Communications, 2021, 57(4): 492-495.

[6]. Jinsung Yang, Simon J. L. Petitjean, Melanie Koehler, Qingrong Zhang, Andra C. Dumitru, Wenzhang Chen, Sylvie Derclaye, Stéphane P. Vincent, Patrice Soumillion, David Alsteens, Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor[J],Nature Communications, 2020, 11(1): 4541.

[7].Wenzhang Chen^#, Ling-Ling Fan, Hai-Tao Xiao, Ying Zhou, Wan Xiao, Jian-Ta Wang, Lei Tang*. First total synthesis of natural products cajanolactone A and cajanonic acid A[J].Chinese Chemical Letters, 2014, 25(5), 749-751.

申请及授权专利：

[1].陈文章,汤磊,夏晶,樊玲玲,王建塔.树豆酮酸A结构类似物、其组合物及

其在药物中的应用, 2017-2-15,中国, ZL201610316137.1.

[2].汤磊,陈文章,彭严,彭金刚,崔杏.带桥环的环己烷二羧酸衍生物及其药物组合物和应用, 2020- 05-07,中国, CN202010384425.2.