晏英
个人简介
2016/3–至今，贵州医科大学、贵州省化学合成药物研发利用工程技术研究中心，副教授
2017/11–2018/5，中科院昆明植物研究所，天然药物化学，高级访问学者，导师：郝小江院士
2013/4–2015/6，中科院昆明植物研究所，天然药物化学，联合培养博士，导师：郝小江院士
2011/9–2015/6，贵州大学精细化工研究开发中心，植物化学，理学博士，导师：郝小江院士
2008/9–2011/6，贵州大学、贵州省中科院天然产物化学重点实验室，天然药物化学，理学硕士，导师：杨小生研究员
2003/9–2007/6，贵州大学，生物科学专业，理学学士
研究方向
黔产药用植物活性天然产物的挖掘及活性天然产物结构优化，主要包括：
1.楝科植物特色天然柠檬苦素类化学成分的综合研究；
2.大戟科大戟属植物的大戟二萜类化学成分研究；
3.西南地区传统药用植物的发掘利用研究。
联系方式（邮箱）
crystal_yanying@126.com
主持科研项目情况
1.黔产大戟属植物中假白榄烷型二萜类化合物激活自噬-溶酶体通路抗阿尔茨海默症活性研究，国家自然科学基金，基金编号：82360687，主持
2.两种植物中抗烟草花叶病毒活性成分的发现、构效关系及作用机制研究，国家自然科学基金，基金编号：31760089，主持
3.具有抗阿尔兹海默症活性的假白榄烷酯类化合物构效关系及作用机制研究，贵州省科学技术基金，基金编号：黔科合基础-ZK[2022]一般393，主持
4.黔产药用植物复叶地黄连中TMV抑制剂的发现、构效关系、作用机制研究，贵州省科学技术基金，基金编号：黔科合基础[2017]1141，主持
5.具有抗阿尔兹海默症活性的假白榄烷酯类化合物构效关系及作用机制研究，贵州省卫健委基金，基金编号：gzwkj2022-222，主持
6.seco-pregnane类C21甾体及其衍生物靶向ERK信号通路抗白血病的作用与机制研究，贵州医科大学学术新苗，基金编号：19NSP083，主持
发表论文、专利及获奖情况
发表论文：
1.Ying Yan, Qi Zhou, Xiaoqian Ran, Qingyun Lu, Cuishan Zhang, Mingyou Peng, Lei Tang, Rongcan Luo*, Yingtong Di*, Xiaojiang Hao, Jatrophane diterpenoids from Euphorbia peplus Linn. as activators of autophagy and inhibit Tau pathology. International Journal of Molecular Sciences, 2023, 24 (2), 1-21.
2.Ying Yan, Jie Chen, Mingyou Peng, Xiong Zhang, Enming Feng, Qindan Li, Bing Guo, Xiao Ding *, Yu Zhang *, Lei Tang *. Sesquiterpenes fromCarpesium faberitriggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells.Phytochemistry,2023, 214, 113805.
3.Ying Yan, Xiaoqian Ran, Dan Wang, Xiong Zhang,Mingyou Peng,Xiaoyan Yan,Lei Tang,Hong Liang,XujieQin,YingtongDi.,Rongcan Luo*,Xiaojiang Hao*, Yonggang Yao*,Munronin V with 7/7/6 tricarbocyclic framework fromMunronia henryiHarms inhibit Tau pathology via activating autophagy,Organic & Biomolecular Chemistry,2023,21 (3): 514-519.
4.Xiong Zhang, Ming-You Peng, Enming Feng, Qingdan Li, Lu Chen, Hucheng Yang,Bing Guo,Hong Liang, Yingtong Di*, Lei Tang*,Ying Yan*.Terpenoids fromEuphorbia helioscopiaand their cytotoxic activities against H1975 cells.Chemistry & Biodiversity2023, 20 (10): e202301061.
5. Jianyi Huang, Ying Yang, Hong Liang, Xuexue Pu, Yingyao Li, Min Cai, Feng Guo, Lin Liu, Mingming Cao,Ying Yan*, Yuanyuan Cheng *, Yingtong Di *, Xiaojiang Hao. Pepluenone, a new pepluane-type diterpenoid with inhibitory activity on the release of NO from the whole plant ofEuphorbia peplusL.Tetrahedron Letters,2023, 123, 154550.
6.Ying Yan, Dan Wang, Xiong Zhang, Mingyou Peng, Xiaoyan Yan, Yushang Guo, Mengao Jia, Jie Zhou, Lei Tang*, Xiaojiang Hao*. Anti-TMV activity and effects of three prieurianin-type limonoids fromMunronia henryi.Pesticide Biochemistry and Physiology,2022, 184, 1-9.
7.Ying Yan, Pan Tang, Xiong Zhang, Dan Wang,Mingyou Peng, Xiaoyan Yan, Zuquan Hu,Lei Tang*,Xiaojiang Hao*, Anti-TMV effects ofseco-pregnane C21 steroidal glycosides isolated from the roots ofCynanchum paniculatum.Fitoterapia,2022, 161, 1-8.
8. Xuexue Pu#,Xiaoqian Ran#,Ying Yan#, Qingyun Lu,Jincun Li,Yingyao Li,Shipeng Guan,Mingming Cao,Jie Liu,Xiaojiang Hao,Rongcan Luo*,YingtongDi*, Three new jatrophane diterpenoids fromEuphorbia peplusLinn. with activity towards autophagic flux.Phytochemistry Letters, 2022,50, 141-146.
9.Jue Yang, Li Chen,Ying Yan, Jianfei Qiu, Juan Chen, Jingrui Song, Qing Rao,Yaacov Ben-David, Yanmei Li, Xiaojiang Hao. BW18, a C-21 steroidal glycoside, exerts an excellent anti-leukemia activity through inducing S phase cell cycle arrest and apoptosis via MAPK pathway in K562 cells.Biomedicine & Pharmacotherapy, 2019, 112, 1-7.
10.Ying Yan, Lei Tang, Jiaqi Hu, Jianta Wang, Tiwalade Adegoke Adelakun, Dongqiong Yang, Yingtong Di, Yu Zhang, Xiaojiang Hao*. Munronin O, a potential activator for plant resistance.Pesticide Biochemistry and Physiology,2018,146, 13–18.
11.Ying Yan, Jianxin Zhang, Tao Huang, Xinying Mao, Wei Gu, Hongpin He, Yingtong Di, Shunlin Li, Duozhi Chen, Yu Zhang*, Xiaojiang Hao*. Bioactive Limonoid Constituents of Munronia henryi.Journal of Natural Products,2015, 78, 811–821.
12.Ying Yan,Chunmao Yuan,Yingtong Di,Tao Huang,Yimin Fan,Yuan Ma,Jianxin Zhang,Xiaojiang Hao*. Limonoids fromMunronia henryiand their anti-tobacco mosaic virus activity.Fitoterapia,2015,107, 29-35.
13.Ying Yan, Jianxin Zhang, Kaixing Liu, Tao Huang, Chen Yan, Liejun Huang, Sheng Liu, Shuzhen Mu, Xiaojiang Hao*.Seco-pregnane Steroidal Glycosides from the Roots ofCynanchum atratumand Their Anti-TMV Activity.Fitoterapia,2014, 97, 50-63.
专利：
1.晏英，罗荣灿，冉晓倩，姚永刚、郝小江、汤磊，王丹，彭明友，张雄.一种柠檬苦素类化合物Munronin V及其制备方法、衍生物和药物组合物及应用,专利号：202211535032.2。
2.晏英，汤磊，王丹，张雄，彭明友.柠檬苦素类化合物、制备方法及其作抗烟草花叶病毒药物的应用，专利号：2021115459566.
获奖情况
2023年，以第一指导教师指导药事管理学本科生获得第十八届“挑战杯”全国大学生课外学术科技作品竞赛省赛一等奖
2022年获校级优秀教师
2021年获得校级青年骨干教师
